Metal complexes with antineoplastic activity

Bioinorganic chemistry: metal complexes with antineoplastic activity

Thiosemicarbazones can affect the activity of ribonucleotide reductase, and hence the synthesis of DNA. Some thiosemicarbazones or thiosemicarbazone complexes, especially complexes with copper(II), can achieve significant inhibition of cell growth. The biological activity of the compounds we synthesize is investigated by assaying their influence on nuclease activity and their cytotoxicity for murine and human cell lines.To obtain compounds with greater bioavailability and cytotoxicity and milder side effects than cis-platin, we are now studying novel mixed complexes of platinum(II) and palladium(II) with α-hydroxycarboxylic acids and amines.
[Pd(MANO)(bipy)]

[Pd(MANO)(bipy)]

[Pt(AcB4DM)(DMSO)]

[Pt(AcB4DM)(DMSO)]

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